Preparation and use of (2-butene-1,4-diyl) magnesium complexes in organic synthesis

ABSTRACT

The magnesium complexes of cyclic hydrocarbons and conjugated dienes, such as 1,2-dimethylenecycloalkanes and 1,3-butadienes, are readily prepared in high yields using highly reactive magnesium. Reactions of these (2-butene-1,4-diyl)magnesium reagents with electrophiles such as dibromoalkanes, alkylditosylates, alkylditriflates, bromoalkylnitriles, esters, or amides serve as a convenient method for synthesizing carbocyclic systems. Significantly, carbocycles prepared by this method contain functional groups such as the exocyclic double bond or a keto group in one of the rings which could be used for further elaboration of these molecules. Furthermore, fused bicyclic systems containing a substituted five-membered ring can be conveniently prepared at high temperatures by the reactions of (2-butene-1,4-diyl)magnesium complexes with carboxylic esters or acid halides whereas low temperatures lead to regioselective synthesis of β,γ-unsaturated ketones. Additionally, γ-lactones, including spiro γ-lactones, can be easily prepared in a one pot synthesis from the reaction of (2-butene-1,4-diyl)magnesium complexes with a ketone or aldehyde and carbon dioxide.

GOVERNMENT SUPPORT

The present invention was made with government support under Grant No. GM35153 awarded by the National Institute of Health. The Government has certain rights in this invention.

CROSS REFERENCE TO RELATED APPLICATIONS

This is a continuation of application Ser. No. 07/949,064, filed Sep. 22, 1992 now abandoned, entitled PREPARATION AND USE OF (2-BUTENE-1,4-DIYL) MAGNESIUM COMPLEXES IN ORGANIC SYNTHESIS which is a Continuation-In-Part of application Ser. No. 07/763,629, filed Sep. 23, 1991 now U.S. Pat. No. 5,231,205.

BACKGROUND OF THE INVENTION

Metallic magnesium reacts with certain 1,3-dienes yielding halide-free organomagnesium compounds. These reactions are typically catalyzed by alkyl halides or transition metal salts. The dienemagnesium compounds produced from these reactions have been mainly limited to open-chain 1,3-dienes, including 1,3-butadiene, 2-methyl-1,3-butadiene, i.e., isoprene, 1-methyl-3-methylene-1,6-octadiene, i.e., myrcene, 2,3-dimethyl-1,3-butadiene, and (E,E)-1,4-diphenyl-1,3-butadiene.

There are problems associated with the preparation of these reagents using metallic magnesium, however. For example, the reaction of metallic magnesium with 1,3-dienes such as 1,3-butadiene or isoprene usually involves dimerization, trimerization, or oligomerization of the product. Furthermore, the reactions are generally accompanied by a variety of by-products. Consequently, the utilization of these reagents in organic synthesis has been quite limited, except for perhaps the use of 1,3-butadiene-magnesium in organometallic synthesis.

It has recently been demonstrated that substituted (2-butene-1,4-diyl)magnesium complexes can be prepared using highly reactive magnesium and 1,4-diphenyl-1,3-butadiene or 2,3-dimethyl-1,3-butadiene. The highly reactive magnesium is produced from MgCl₂, Li, and naphthalene in tetrahydrofuran. The substituted (2-butene-1,4-diyl) magnesium complexes produced are halide-free organomagnesium reagents, i.e., bis-Grignard reagents, containing two formal Mg--C bonds in one organic species. They have been shown to function as bisnucleophiles in reactions with electrophiles. For example, these bis-Grignard reagents formed from 1,3-butadienes react with α,ω-alkylene dihalides in either 1,2-, 1,4-, or 2,1- additions to give complex carbocycles.

Although reactions of highly reactive magnesium with symmetrical 1,3-dienes, specifically, 1,4-diphenyl-1,3-butadiene and 2,3-dimethyl-1,3-butadiene, have been shown, reactions with more complex 1,3-dienes have not been discussed to any significant extent in the literature. Thus, it is an object of this invention to prepare (2-butene-1,4-diyl)magnesium complexes from more complex 1,3-diene systems than simple symmetrical 1,3-butadienes such as 1,4-diphenyl-1,3-butadiene and 2,3-dimethyl-1,3-butadiene. Furthermore, it is an object of this invention to utilize such (2-butene-1,4-diyl)magnesium complexes in organic synthesis. It is also an object of the present invention to utilize the organomagnesium reagents produced from 1,3-dienes in the preparation of complex organic molecules.

SUMMARY OF THE INVENTION

The present invention is directed to a method for the preparation of carbocycles, spiroheterocycles such as silicon-containing spiroheterocycles, and γ-lactones including spiro γ-lactones. Herein, carbocycles refer to cyclic carbon-containing molecules. This includes spirocycles and fused-ring hydrocarbon systems. Herein, spirocycles refer to molecular structures with two rings having one atom in common. This atom is typically a carbon atom; however, for the silicon-containing spiroheterocycles, for example, this atom is a silicon atom.

The method of preparing carbocycles consists of: contacting a magnesium(II) salt in an ethereal, polyethereal, or hydrocarbon solvent, preferably an ethereal or polyethereal solvent, and more preferably tetrahydrofuran, with a reducing agent having a reduction potential of about -1.5 volts, or more negative, relative to standard calomel electrode (SCE), to form a highly reactive magnesium species; contacting the highly reactive magnesium species with a cyclic hydrocarbon containing at least two conjugated exocyclic double bonds to form a (2-butene-1,4-diyl)magnesium complex; and contacting the (2-butene-1,4-diyl)magnesium complex with an electrophile to form a carbocycle. The carbocycles formed are preferably spirocycles, fused ring carbocyclic alcohols, and β,γ-unsaturated ketones.

The reducing agent used in the step of forming the highly reactive magnesium species is preferably an alkali metal salt, i.e., Li, Na, K, Rb, Cs, of an aromatic anion. More preferably, the reducing agent is selected form the group consisting of sodium naphthalenide, sodium anthracenide, sodium biphenylide, lithium naphthalenide, lithium anthracenide, and lithium biphenylide.

Most preferably, the reducing agent is lithium naphthalenide, preferably preformed lithium naphthalenide.

The cyclic hydrocarbon is preferably a cycloalkane containing at least two conjugated exocyclic double bonds, and more preferably, a cycloalkane containing two conjugated exocyclic double bonds. More preferably, the cyclic hydrocarbon is selected from the group consisting of 1,2-dimethylenecyclohexane, 1,2-dimethylenecyclopentane, and 1,2-dimethylenecycloheptane. The step of contacting the highly reactive magnesium species with the hydrocarbon is preferably carried out in an ethereal or polyethereal solvent.

The electrophiles used in the reaction with the (2-butene-1,4-diyl)magnesium complexes to form spirocycles, i.e., spirocyclic carbocycles, are preferably selected from the group consisting of organodihalides, organoditosylates, organoditriflates, haloalkylnitriles, esters, and amides. More preferably, the electrophiles are selected from the group consisting of alkyldibromides, alkylditosylates, and bromoalkylnitriles. The step of contacting the (2-butene-1,4-diyl)magnesium complex with an electrophile to form a spirocycle is preferably carried out at a temperature below about 100° C., and in an ethereal or polyethereal solvent.

The present invention is also directed to a method for the preparation of a fused ring carbocyclic alcohol and a method for the preparation of β, γ-unsaturated ketones. The method for the preparation of a fused ring carbocyclic alcohol includes a step of contacting the (2-butene-1,4-diyl)magnesium complex, prepared from the highly reactive magnesium and a cyclic hydrocarbon containing at least two conjugated exocyclic double bonds, with a carboxylic ester or acid halide. This reaction is carried out at a temperature of about 25° C. or greater, preferably in an ethereal or polyethereal solvent. By changing the reaction temperature of this latter step of the reaction, β,γ-unsaturated ketones can be prepared. That is, by contacting the (2-butene-1,4-diyl)magnesium complex with a carboxylic ester or acid halide, preferably in an ethereal or polyethereal solvent, at a temperature of below about -10° C., a β,γ-unsaturated ketone is formed.

The method for the preparation of spiroheterocycles, preferably silicon-containing spiroheterocycles, is similar to the method for the preparation of carbocycles in that a highly reactive magnesium species is initially formed. This highly reactive magnesium species is then combined with an unsymmetrical 1,3-diene to form a (2-butene-1,4-diyl)magnesium complex. This complex is then combined with a tetrahalide reagent of the formula MX₄ (wherein M=Si, Ge, Sn, Pb and X=F, Cl, Br, I), to form a spiroheterocycle. Preferably, a silicon tetrahalide, such as SICl₄, is used to form a silicon-containing spiroheterocycle.

The present invention is also directed to a method for the preparation of γ-lactones, particularly spiro γ-lactones. This method includes the steps of: contacting a magnesium(II) salt in an ethereal, polyethereal, or hydrocarbon solvent with a reducing agent having a reduction potential of about -1.5 volts, or more negative, relative to SCE, to form a highly reactive magnesium species; contacting the highly reactive magnesium species with a conjugated diene to form a (2-butene-1,4-diyl)magnesium complex; contacting the (2-butene-1,4-diyl)magnesium complex with a ketone or aldehyde in an ethereal, polyethereal, or hydrocarbon solvent to form a 1,2-addition adduct resulting from the incorporation of one molecule of the ketone or aldehyde to the (2-butene-1,4-diyl)magnesium complex; contacting the 1,2-addition adduct with carbon dioxide to form a nucleophilic addition product; and contacting the nucleophilic addition product with an aqueous acid to form a γ-lactone, preferably a spiro γ-lactone. The conjugated diene can be a cyclic hydrocarbon containing at least two conjugated exocyclic double bonds, as discussed above, or an open-chain conjugated diene, such as 2,3-dimethyl-1,3-butadiene. The ketone and aldehyde can be any aryl or alkyl ketone or aldehyde including those containing heteroatoms, such as nitrogen. For example, the ketone can be any cyclic ketone such as cyclohexanone to yield a spiro γ-lactone, or it can be an acyclic ketone to yield a γ-lactone. Any alkyl or aryl aldehyde would yield a γ-lactone.

DETAILED DESCRIPTION

The present invention is directed to the discovery that novel (2-butene-1,4-diyl)magnesium complexes can be prepared using a highly reactive magnesium metal species and symmetrical or unsymmetrical 1,3-dienes. Specifically, the invention involves a method for the one-step formation of spirocycles, fused ring carbocyclic alcohols, β,γ-unsaturated ketones, and γ-lactones, including spiro γ-lactones, using suitable electrophiles and (2-butene-1,4-diyl)magnesium complexes prepared from either cyclic hydrocarbons containing at least two conjugated exocyclic double bonds or open-chain hydrocarbons containing at least two conjugated double bonds. Also, spiroheterocycles, such as silicon-containing spiroheterocycles, can be prepared from unsymmetrical (2-butene-1,4-diyl)magnesium complexes using a tetrahalide reagent of the formula MX₄ (wherein M=Si, Ge, Sn, Pb and X=F, Cl, Br, I), preferably a silicon tetrahalide. The invention also involves a method for the control of the regioselectivity of electrophilic attack of unsymmetrical (2-butene-1,4-diyl)magnesium complexes using triorganosilyl chlorides prior to reaction with a second electrophile.

The Magnesium Species

The highly reactive magnesium species of the present invention is prepared from the reduction of a substantially anhydrous magnesium(II) salt, the counterion of which can be any of a variety of anions that does not contain an acidic proton. For example, the anion can be a sulfate, nitrate, nitrite, cyanide, or halide. Preferably, the anion is a halide or cyanide. More preferably, the anion of the Mg(II) salt is Cl, F, Br, or I, and most preferably Cl.

Generally, the reducing agent can be any reducing agent that is capable of reducing Mg(II) salts in an ethereal, polyethereal, or hydrocarbon solvent. Any reducing agent having a reduction potential of about -1.5 volts or more negative, relative to the standard calomel electrode (SCE), will satisfy this relation. It is preferred, however, that the reducing agent has a reduction potential of about -1.8 volts or more negative, and most preferred that the reducing agent has a reduction potential of about -2.0 volts or more negative, relative to SCE. Examples of useable reducing agents include: alkali and alkaline earth metals; alkali and alkaline earth metal salts of aromatic anions (i.e., aromatic electron transfer compounds), such as sodium naphthalenide or lithium naphthalenide; metal hydrides, such as sodium borohydride and sodium hydride; metal intercalated graphites; and alkali metals dissolved in glymes or ethers.

Preferably, the reducing agent is an alkali metal reducing agent, such as an alkali metal, an alkali metal dissolved in glymes or ethers, or an alkali metal salt of an electron transfer compound. More preferably, the reducing agent is an alkali metal salt of an electron transfer compound, i.e., a combination of an alkali metal cation and an anion of an electron transfer compound, referred to herein as an "alkali metal complex." The electron transfer compound is preferably an aromatic electron transfer compound such as biphenyl, anthracene, or naphthalene. Examples of useful "alkali metal complex" reducing agents include, but are not limited to, complexes of an alkali metal and an aromatic electron transfer compound; alkali metal-polyether solvates; alkali metal-crown ether solvates; alkali metal-cryptate solvates, etc. Examples of a complex of an alkali metal and an aromatic electron transfer compound, i.e., aromatic anion, include sodium naphthalenide, lithium naphthalenide, sodium anthracenide, lithium anthracenide, sodium biphenylide, lithium biphenylide, and the like. Most preferably, the reducing agent is an alkali metal arene salt, i.e., a complex of an alkali metal and an aromatic electron transfer compound, the most preferred of which is lithium naphthalenide.

In certain preferred embodiments the alkali metal complex reducing agent is preformed. By "preformed" it is meant that the alkali metal and about 1.0-1.2 moles of the electron transfer compound per mole of the alkali metal, are allowed to react substantially completely, i.e., until substantially all the alkali metal is consumed, before contacting any magnesium salts. The formation of the preformed reducing agent typically takes place in an ethereal, polyethereal, or hydrocarbon solvent, and generally is substantially complete in less than about eight hours, preferably in less than about two hours.

The highly reactive magnesium species is composed of formally zerovalent magnesium metal atoms in the form of a finely divided black powder. By "formally zerovalent" it is meant that the formal oxidation state, or charge, is equal to the group number (i.e., 2) minus the number of unshared electrons (i.e., 2) minus the number of bonds (i.e., 0). Preferably, the zerovalent highly reactive magnesium species is a mixture or combination of zerovalent magnesium metal atoms and an alkali metal salt. The alkali metal salt is preferably a salt of the counterion associated with the Mg(II) salt from which the highly reactive magnesium species was prepared.

The highly reactive magnesium powder typically settles out of solution after a few hours leaving a clear solution. The solvent can then be removed via cannula. The metal powder can then be washed to remove the electron carrier as well as the alkali metal salt produced from the cation of the aromatic reducing agent and the anion of the magnesium salt starting material if so desired. Although the highly reactive magnesium is preferably washed prior to further reaction, it can contain residual alkali metal salt.

The process for reduction to produce the highly reactive magnesium species of the present invention is conducted under conditions designed to prevent its reoxidation. Generally, these conditions include use of a nonhydroxylic solvent, such as ethereal, polyethereal, or hydrocarbon solvents and the exclusion of oxygen. Preferably, these conditions include temperatures of about 100° C. or less, an inert atmosphere, e.g., an argon or nitrogen atmosphere, a reaction time of about two hours or less. More preferably, the temperature is about 80° C. or less, and most preferably the reduction of the Mg(II) salt is conducted at ambient temperatures, i.e., at about 20°-30° C.

Examples of useable solvents include dimethyl ether, diethyl ether, methyl-t-butyl ether, tetrahydrofuran (THF), 1,2-dimethoxyethane (DME or glyme), diglyme, triglyme, benzene, xylene, hexanes, and the like. More preferably, the reduction of the Mg(II) salt is carried out in an ethereal or polyethereal solvent such as diethyl ether, dimethyl ether, tetrahydrofuran, and the like, and most preferably in tetrahydrofuran (THF). If a hydrocarbon solvent (e.g., benzene, xylene, hexanes, etc.) is used, it preferably contains a secondary solubilizing agent such as N,N,N',N'-tetramethylethylenediamine (TMEDA) to assist in solubilizing the starting materials. If the reducing agent is an alkali metal reducing agent, but not an alkali metal salt of an electron transfer compound, the solvent is one whose boiling point exceeds the melting point of the alkali metal.

Typically, the molar ratio of the reducing agent to the Mg(II) salt is about 2:1; however, the Mg(II) salt can be in excess. Preferably, the Mg(II) salt is present in an amount of about 0.8-1.2 moles per 1.8-2.2 moles of a one-electron reducing agent. It is often desirable, however, to use a slight excess of the magnesium salt relative to the alkali metal, to decrease the chance that the reducing agent could interfere with the subsequent use of the highly reactive magnesium.

There are several methods of preparation of the zerovalent highly reactive magnesium species of the present invention. For example, the Mg(II) salt can be prepared by the combination of an alkali metal, such as K or Na, in a solvent whose boiling point exceeds the melting point of the alkali metal, such as THF or glyme. By this, it is meant that about two moles, i.e., about 1.8-2.2 moles, of an alkali metal are used per mole of magnesium salt. This method is represented by Example 1.

Another method for the preparation of the reactive magnesium species involves a one-step reduction of a Mg(II) salt in the presence of an electron transfer compound. This method is represented by the reduction of MgCl₂ in Example 2. Specifically, this method includes the reduction of a Mg(II) salt in the presence of an alkali metal, such as lithium, and an effective catalytic amount of an electron transfer compound, such as the aromatic electron transfer compound naphthalene. With respect to this method, by an "effective catalytic amount" it is meant that a sufficient amount of the electron transfer compound is present to effect the reduction in less than about three hours, preferably in less than about two hours. The electron transfer compound is typically present in no greater than about 10 mole-%, preferably no greater than about 6 mole-%, and most preferably within a range of about 2 mole-% to about 5 mole-%, of the alkali metal present. The alkali metal is present in an amount of about 1.8-2.2 moles per mole of magnesium salt being reduced.

A third method for the preparation of a reactive magnesium species involves a two-step reduction of a Mg(II) salt using a preformed reducing agent. This method is represented by the reduction of MgCl₂ in Example 3. The magnesium salt in a solvent, e.g., MgCl₂ in THF, is transferred into the solution of the preformed reducing agent, e.g., lithium naphthalenide in THF. Alternatively, the preformed reducing agent can be added to the magnesium salt. The reduction of the Mg(II) salt in the second step of this two step method using a preformed reducing agent is typically carried out in less than about eight hours, preferably in less than about two hours, and more preferably in less than about one hour. Preferably, the total reaction time for both steps is less than about eight hours.

A fourth method for the preparation of a reactive magnesium species involves a two-step reduction of a Mg(II) salt in the presence of an electron transfer compound and an excess of an alkali metal. This method is represented by the reduction of MgCl₂ in Example 4. The reducing agent is formed from an alkali metal and an effective catalytic amount of an electron transfer compound. By an "effective catalytic amount" it is meant that a sufficient amount of the electron transfer compound is present to effect the reduction in less than about three hours, preferably in less than about two hours. Preferably, this involves the use of no greater than about 10 mole-% of the electron transfer reagent, more preferably no greater than about 6 mole-%, and most preferably within a range of about 2-5 mole-%, of the alkali metal present. The alkali metal is present in an amount of about 1.8-2.2 moles per mole of magnesium salt being reduced. Thus, a solution of the resultant alkali metal complex reducing agent, i.e., the complex of the alkali metal and electron transfer compound, contains unreacted alkali metal.

A magnesium salt, preferably a magnesium salt solution, e.g., MgCl₂ in THF, or a magnesium salt suspension, is then slowly transferred into the solution of the alkali metal reducing agent, e.g., lithium naphthalenide in THF, containing unreacted alkali metal, e.g., lithium. By "slowly" it is meant that the Mg(II) salt is added to the solution of the reducing agent containing unreacted alkali metal at a rate that ensures the presence of excess alkali metal complex reducing agent relative to solubilized Mg(II) salt. This is evidenced by adding the Mg(II) salt at a rate such that the color of the reducing agent solution remains dark green, if a complex of an alkali metal and aromatic electron transfer compound is used. Although not intending to be a limitation to the invention in any way, it is believed that as the reducing agent is consumed, the recovered naphthalene reacts with the unreacted lithium to form lithium naphthalenide until all the lithium is consumed. This is unexpected because the small amount of electron carrier is expected to lead to long reduction times of several hours and even days, rather than minutes. In contrast, the relatively short reduction times with small amount of electron carrier makes this an especially appealing method.

The alkali metal complex reducing agents, e.g., lithium naphthalenide, can also be generated by electrochemical reduction of an electron transfer compound, e.g., naphthalene, using an alkali metal salt, e.g., a lithium halide, as the electrolyte. That is, an alkali metal complex reducing agent can be formed electrochemically. This can be carried out in an electrochemical cell containing an ethereal or polyethereal solvent using an electrode of palladium, platinum, carbon, or gold. Useful electrodes can be in any of a variety of forms. They can be solid, porous, or in the form of a slurry. The electrochemical route is advantageous and preferred at least because it avoids the use of alkali metals, which can be quite dangerous.

As a representative example of this procedure, naphthalene can be reduced in an inert atmosphere in the presence of a lithium salt, as the electrolyte, in THF. The electrode can be a large surface area electrode to facilitate the reduction. Once the lithium naphthalenide is formed, it can be transferred to the magnesium salt, or the magnesium salt can be transferred to it, for formation of the zerovalent highly reactive magnesium.

Although the magnesium species can be maintained for a time under an inert atmosphere and ambient temperatures, it is also quite reactive. Consequently, it is preferably synthesized and used immediately or within a very short period of time. However, it can be stored for long periods of time under an inert atmosphere.

The magnesium species of this invention will react with symmetrical and unsymmetrical 1,3-diene compounds to produce selectively reactive (2-butene-1,4-diyl)magnesium compounds. These organomagnesium species undergo a variety of reactions to produce both novel organic compounds and novel synthetic methods for known organic compounds. One type of novel (2-butene-1,4-diyl)magnesium complex results from the reaction of this highly reactive magnesium with cyclic hydrocarbons containing at least two conjugated exocyclic double bonds, such as occur in 1,2-dimethylenecyclohexane, 1,2-dimethylenecyclopentane, and 1,2-dimethylenecycloheptane, for example.

Spiroannelation

Highly reactive magnesium reacts smoothly with cyclic hydrocarbons containing at least two conjugated exocyclic double bonds to produce the corresponding (2-butene-1,4-diyl)magnesium complexes in high yield. The cyclic hydrocarbons can be any of a variety of cyclic alkanes or cyclic alkenes containing at least two conjugated exocyclic double bonds providing, however, that any double bonds in the ring are not in conjugation with the exocyclic double bonds. Preferably, these cyclic hydrocarbons do not contain any additional functional groups that react with the highly reactive magnesium preferentially to the conjugated exocyclic double bond functionalities. More preferably, the cyclic hydrocarbons are cycloalkanes containing at least two exocyclic double bonds. Most preferably, the cycloalkanes are 1,2-dimethylenecycloalkanes, such as 1,2-dimethylenecyclohexane, 1,2-dimethylenecyclopentane, and 1,2-dimethylenecycloheptane. These resulting (2-butene-1,4-diyl)magnesium complexes prepared from cyclic hydrocarbons with conjugated exocyclic double bonds react with a variety of electrophiles, i.e., compounds that are deficient in electrons, to form carbocycles, including spirocycles, i.e., structures with two rings having one carbon atom in common (Tables I and II). Spirocycles, particularly the spiro[4.5]decane and spiro[5.5]undecane ring systems, constitute the basic carbon framework found in a wide variety of naturally occurring sesquiterpenes.

The electrophiles include, but are not limited to, organodihalides, such as 1,2-dibromoethane, 1,3-dibromopropane, 1,4-dibromobutane, and 1,5-dibromopentane, organoditosylates, such as ethylene glycol di-p-tosylate, haloalkylnitriles, such as Br(CH₂)_(n) CN compounds wherein n=1-3, organoditriflates, esters, amides, and the like. The reactions with the electrophiles typically yield carbocycles in isolated yields greater than about 40%, and often greater than about 50%.

Significantly, a wide variety of ring sizes can be generated using this approach, making this an advantageous method for the easy preparation of a wide variety of carbocycles, particularly spirocycles. Furthermore, the spirocycles typically formed by this method contain functional groups, such as an exocyclic double bond or a keto group, in one of the rings that can be used for further elaboration of these molecules.

The reaction conditions for production of (2-butene-1,4-diyl)magnesium complexes resulting from the reaction of highly reactive magnesium with cyclic hydrocarbons having conjugated exocyclic double bonds include ambient temperatures, i.e., about 20° C. to 30° C., the absence of oxygen, and an excess of highly reactive magnesium. Generally, these conditions include use of ethereal, polyethereal, or hydrocarbon solvents. Preferably, the reactions are carried out under an inert atmosphere of argon or nitrogen with a ratio of magnesium to cyclic hydrocarbon present in a range of about 1:1 to 2:1 molar equivalents. The reaction time is preferably 3-4 hours, and the solvent is preferably an ether or polyether solvent such as diethyl ether, dimethyl ether, tetrahydrofuran, and the like. More preferably, the solvent is tetrahydrofuran.

The subsequent reactions of these (2-butene-1,4-diyl)magnesium complexes with electrophiles to produce carbocycles, particularly spirocycles include temperatures of less than about 100° C., preferably at a temperature of about -80° C. to about 80° C., and the absence of oxygen. Generally, these reactions are carried out in ethereal, polyethereal, or hydrocarbon solvents. Preferably, the reactions are carried out in tetrahydrofuran under an inert atmosphere of argon or nitrogen at a temperature of about -78° C. with subsequent warming. The keto-functionalized products also include a step whereby H₃ O⁺ is added subsequent to warming.

Fused Ring Carbocyclic Alcohols and β,γ-Unsaturated Ketones

This chemistry can also be extended to the construction of fused ring carbocycles, which are present in many naturally occurring sesquiterpenes. For example, fused carbocyclic alcohols can be obtained by the reaction of (2-butene-1,4-diyl)magnesium complexes prepared from cyclic hydrocarbons containing two conjugated exocyclic double bonds with carboxylic esters and acid halides, particularly acid chlorides. These reactions can be also used to prepare carbocycles containing a β,γ-unsaturated ketone functionality simply by controlling the reaction temperature (Table III).

This approach is of general synthetic utility for the preparation of fused carbocyclic alcohols or β,γ-unsaturated ketones depending on the reaction temperatures. That is, treatment of (2-butene-1,4-diyl)magnesium complexes, prepared as described above, with carboxylic esters or acid halides at temperatures below about -10° C. and quenching the reactions at -10° C. results in the formation of β,γ-unsaturated ketones in isolated yields of at least about 50%. On the other hand, warming the mixture to room temperature, i.e., 25° C. or greater, preferably up to refluxing temperatures, followed by workup and isolation affords a fused carbocyclic alcohol in isolated yields of at least about 50%.

The further addition of an acid halide, preferably an acid chloride, at a temperature below about -10° C., preferably below about -20° C., alternatively can lead to the formation of spirocyclic carbocycle containing a three-membered ring. That is, a (2-butene-1,4-diyl)magnesium complex can be combined with a carboxylic ester or a first acid halide, preferably an acid chloride, and then combined with a second acid halide, which can be the same as the first acid halide, to form a carbocyclic spirocycle containing a three-membered ring. This is represented by the third and last examples in Table III.

The reactions leading to β,γ-unsaturated ketones are typically regioselective, i.e., there is generally no double bond scrambling. This feature should provide a new entry to the regioselective synthesis of β,γ-unsaturated ketones from 1,3-dienes. Furthermore, the overall process from 1,2-dimethylenecycloalkanes to the corresponding fused carbocyclic alcohols represents a formal [4+1] annulation which serves as an easy route to the hydroindene, hydropentalene, and hydroazulene bicyclic systems.

The carboxylic esters or acid halides, particularly acid chlorides, used in these reactions can be any of a variety, such as, for example ethyl acetate, ethyl butyrate, ethyl benzoate, and acetyl chloride. These reactions can be carried out in ethereal, polyethereal, or hydrocarbon solvents. Preferably, they are carried out in the tetrahydrofuran.

Preparation of γ-Lactones Including Spiro γ-Lactones

A useful application of substituted (2-butene-1,4-diyl)magnesium complexes formed from a conjugated diene, e.g., either cyclic hydrocarbons containing at least two conjugated exocyclic double bonds or open-chain hydrocarbons containing at least two conjugated double bonds, is the novel one-pot synthesis of γ-lactones, preferably spiro γ-lactones (Table IV). The cyclic hydrocarbons useful in this synthetic method are the same as those discussed above with respect to spiroannelation. The open-chain conjugated dienes can be a variety of dienes containing at least two double bonds in conjugation, i.e., separated by a carbon-carbon single bond. Preferably, these open-chain conjugated dienes do not contain any additional functional groups that react with the highly reactive magnesium preferentially to the conjugated double bond functionalities. More preferably, the open chain conjugated dienes are 1,3-dienes. Most preferably the open chain conjugated dienes are 1,3-butadienes, such as 2,3-dimethyl-1,3-butadiene.

Spiro γ-lactones and other γ-lactones can be obtained in yields in excess of 50%, preferably in excess of 60%, by initially treating (2-butene-1,4-diyl)magnesium complexes at a temperature of -90° C. to -70° C. with a ketone or aldehyde to give the corresponding 1,2-addition adduct. The ketone or aldehyde is preferably present in an amount of approximately one mole of ketone or aldehyde per mole of (2-butene-1,4-diyl)magnesium complex. The ketones can be any alkyl, aryl, or mixed alkyl-aryl ketone. Preferably, the ketone is selected from the group consisting of acetone, cyclohexanone, and cyclopentanone. The aldehydes can be any alkyl or aryl aldehyde. Preferably, the aldehyde is selected from the group consisting of benzaldehyde and acid aldehyde. It is noted that the aryl ketones and aryl aldehydes include within their scope groups containing heteroatoms such as nitrogen, for example.

Subsequent to this initial step, carbon dioxide is combined with the 1,2-addition adduct to form a nucleophilic addition product. This reaction is preferably carried out by bubbling gaseous carbon dioxide through the reaction mixture containing the 1,2-addition adduct. This nucleophilic addition product is a magnesium salt of an organic molecule containing both an alkoxy and a carboxylate group (--COO⁻). The nucleophilic addition reaction with CO₂ preferably occurs at a temperature of about 0° C. to about 25° C. Acidic hydrolysis using an aqueous acid, followed by a slight warming of the reaction mixture to a temperature of about 30° C. to about 50° C. forms the γ-lactone. The aqueous acid is preferably a strong mineral, i.e., inorganic, acid. More preferably, the acid is selected from the group consisting of HCl, H₂ SO₄, and H₃ PO₄. Most preferably, the acid is HCl. Significantly, this approach can also be used to prepare spiro γ-lactones containing two spiro centers. The representative examples of this dispiroannulation are listed in Table IV (Entries 2 and 3).

Preparation of Spiroheterocycles

One of the useful applications of substituted (2-butene-1,4-diyl)magnesium complexes formed from unsymmetrical 1,3-dienes is the facile synthesis of spiroheterocyclic compounds. Significantly, double annelation can be accomplished in one step by treating unsymmetrical (2-butene-1,4-diyl)magnesium complexes with MX₄ (wherein M=Si, Ge, Sn, Pb and X=F, Cl, Br, I) to form spiroheterocycles (Table V).

Although it is particularly difficult to prepare unsymmetrical (2-butene-1,4-diyl)magnesium complexes from ordinary magnesium due to extensive polymerization, the use of highly reactive magnesium circumvents this problem. For example, an excess of newly generated highly reactive magnesium reacts with unsymmetrical 1,3-dienes, such as, for example, isoprene, myrcene, or 2-phenyl-1,3-butadiene, in an ethereal, polyethereal, or hydrocarbon solvent at room temperature in about 2 hours to give the corresponding unsymmetrical (2-butene-1,4-diyl)magnesium complexes. The reactions are preferably carried out in THF. The color of the resulting complexes varies with the diene: pale orange for isoprene; light olive for myrcene; and reddish brown for 2-phenyl-1,3-butadiene.

Typically, the reaction to form a silicon-containing spiroheterocycle involves the combination of an excess of an unsymmetrical 1,3-diene with a silicon tetrahalide under extremely mild conditions. Other spiroheterocycles can be obtained from the appropriate tetrahalide reagent. Examples include SnCl₄, PbCl₄, and GeCl₄. These would yield the corresponding Sn, Pb, and Ge spiroheterocycles, respectively.

The reaction conditions include temperatures below about 25° C., and preferably within a range of about -80° C. to about 0° C. Most preferably the reactions are carried out at -78° C. for about 30 minutes followed by warming to 0° C. The reactions are typically carried out in an ethereal, polyethereal, or hydrocarbon solvent and in the absence of oxygen. Preferably, the reactions are carried out under an inert atmosphere such as nitrogen or argon in tetrahydrofuran.

Regioselective Reactions of Unsymmetrical (2-Butene-1,4-diyl)magnesium Reagents with Two Different Electrophiles

One of the major differences in chemistry between unsymmetrical and symmetrical (2-butene-1,4-diyl)magnesium complexes originates from the fact that the former possesses four totally different reactive sites and the latter has only two nonidentical nucleophilic centers. Accordingly, the regiochemistry of electrophilic attack is one of the essential problems associated with the reactions of unsymmetrical (2-butene-1,4-diyl)magnesium complexes. Treatment of unsymmetrical (2-butene-1,4-diyl)magnesium complexes with triorganosilyl chloride followed by cyclohexanone affords a stepwise addition across a terminal double bond with high regioselectivity. The results of the regioselective reactions are summarized in Table VI.

Typically, the conditions of the regioselective reactions include temperatures below about 25° C., preferably within a range of about -80° C. and 0° C., and the absence of oxygen. The solvent is generally an ethereal, polyethereal, or hydrocarbon solvent. Preferably, the regioselective reactions are carried out with the unsymmetrical (2-butene-1,4-diyl)magnesium complex and an organosilicon reagent, such as Me₃ SiCl, in THF at a temperature of about -80° C. to 0° C. This is followed by the addition of an excess of a second electrophile, such as cyclohexanone. Subsequently, the reaction mixture is warmed to room temperature and the products isolated. Preferably, the organisilicon reagent is a compound of the formula R₃ SiCl wherein R=C₁ -C₄ alkanes. More preferably, the organosilicon reagent is Me₃ SiCl and (n-butyl)₃ SiCl.

In a typical example, it is believed that the initial attack of the complex by the organosilicon reagent determines the selectivity, which was found to be generally dependent on both the diene substrate and the initial electrophile. The reaction of (2-methyl-2-butene-1,4-diyl)magnesium with trimethylsilyl chloride resulted in initial attack at the 4 or 1-position, producing two isomers of allylic Grignards. Reports of ¹ H NMR studies reveal that substituted allylic Grignard reagents exist as a rapidly equilibrating mixture of Z and E primary stereoisomers. Treatment of the allylic Grignards with cyclohexanone leads to overall additions across a terminal double bond.

Increasing the size of the organosilicon reagent results in increased regioselectivity. This was demonstrated by using tri(n-butyl)silyl chloride as the initial electrophile. Larger substituents at the 2-position of the diene can also increase selectivity. For example, the magnesium complex of myrcene reacted with trimethylsilyl chloride, followed by cyclohexanone, to yield 1-(2-(4-methyl-3-pentenyl)-1-trimethylsilylmethyl-2-propenyl)cyclohexanol and 1-(1-ethenyl-5-methyl-l-trimethylsilylmethyl-4-hexenyl)cyclohexanol in a 94:6 ratio. Furthermore, a single isomer is obtained in excellent yield by replacing the first electrophile with tri(n-butyl)silyl chloride.

The invention will be further exemplified with respect to the various specific and preferred embodiments and techniques. It should be understood, however, that many variations and modifications may be made while remaining within the scope of the invention.

EXPERIMENTAL EXAMPLES

General Aspects

¹ H NMR (360 MHz) spectra were recorded in CDCl₃ solution unless specified. All chemical shifts are reported in parts per million (δ) downfield from internal standard tetramethylsilane. Fully decoupled ¹³ C NMR (50 MHz) spectra were recorded in CDCl₃ solution. The center peak of CDCl₃ (77.0 ppm) was used as the internal reference. FTIR spectra are reported in cm⁻¹. Mass spectra were performed by the Midwest Center for Mass Spectrometry at the University of Nebraska-Lincoln.

All manipulations were carried out under an atmosphere of argon on a dual manifold vacuum/argon system. The Linde™ prepurified grade argon was further purified by passage through a BASF™ R3-11 catalyst column at 150° C., a phosphorous pentoxide column, and a column of granular potassium hydroxide. Lithium, potassium, naphthalene, and MgCl₂ were weighed out and charged into reaction flasks under argon in a vacuum Atmospheres Company dry box. Tetrahydrofuran (THF) was distilled from Na/K alloy under an atmosphere of argon immediately before use. All other reagents were used as received unless otherwise specified.

Gas chromatographic analyses were done on a Hewlett-Packard™ 5890A chromatograph using stainless steel columns (12 feet× 1/8 inches) packed with OV-17 (3%) on 100/120 Chromosorb™ G-AW or SE-30 (5%) on 100/120 Chromosorb™ G-NAW (available from Supelco Inc.). Preparative gas chromatographic separations were obtained on a Varian Aerograph™ (model 920) chromatograph equipped with a stainless steel column (12 feet× 1/4 inches) packed with GP 10% SP 2100 on 100-120 Supelcoport (available from Supelco Inc.). Analytical thin-layer chromatography was performed using Merck™ 5735 indicating plates precoated with silica gel 60 F₂₅₄ (layer thickness 0.2 mm) (available from Analtech Inc.). Preparative thin-layer chromatographic separations were obtained using Anatech™ silica gel GF (layer thickness 2 mm) preparative plates (available from Analtech Inc.) or using Whatman™ PLKC 18F linear-K (layer thickness 1 mm) reversed phase preparative plates (available from Analtech Inc.). Liquid chromatographic purifications were performed by flash column chromatography using glass columns packed with Merck™ silica gel 60 (230-400 mesh) (available from Analtech Inc.). Low-temperature conditions were obtained utilizing a Neslab Endocal™ ULT-80 refrigerated circulating bath or utilizing dry ice/acetone baths.

Highly Reactive Magnesium

Highly reactive magnesium can be prepared by several acceptable methods. These methods are represented by Examples 1-4. Once the highly reactive magnesium powder was formed, it was allowed to settle. The supernatant was then drawn off, and freshly distilled THF was added, followed by the appropriate 1,3-diene. [Note: The moles of highly reactive magnesium refer to the theoretical amount possible, based on the original amount of magnesium chloride.]

EXAMPLE 1

Preparation of Highly Reactive Magnesium From Magnesium Halide and an Alkali Metal

In a typical preparation, potassium (20.8 mmol) and anhydrous magnesium chloride (10.0mmol) in freshly distilled THF were stirred under argon for 1-2 hours at refluxing THF temperature. The reduction yielded a highly reactive finely divided black powder.

EXAMPLE 2

One-Step Reduction of a Magnesium Halide with an Alkali Metal with a Catalytic Amount of Naphthalene

A predried 50 mL, two-necked, round-bottomed flask was charged with lithium (30.0 mmol), a catalytic amount of naphthalene (1.6 mmol), anhydrous MgCl₂ (15.0 mmol), and freshly distilled THF (15 mL) in an argon atmosphere drybox. The mixture was stirred at room temperature for about 30 minutes. A highly reactive magnesium species was formed.

EXAMPLE 3

Two-Step Reduction of a Magnesium Halide with Preformed LiNp

In a typical preparation, lithium (10.0 mmol) and naphthalene (10.8 mmol) in freshly distilled THF (15 mL) were stirred under argon until the lithium was completely consumed (approximately 2 hours). The resulting dark green lithium naphthalenide was then transferred dropwise via a cannula into a THF solution (10 mL) of anhydrous magnesium chloride (4.8 mmol). The mixture was stirred at room temperature for 30 minutes. The newly formed magnesium slurry was allowed to settle for at least 3 hours and then the supernatant was drawn off via a cannula.

EXAMPLE 4

Two-Step Reduction of a Magnesium Halide with an Alkali Metal with a Catalytic Amount of Naphthalene

Two 50-mL two-necked flasks, A and B, are equipped with rubber septa, condensers topped with argon inlets, and Teflon™-coated magnetic stir bars. Flask A is charged with freshly cut lithium (30.0 mmol) and a catalytic amount of naphthalene (1.5 mmol). Flask B is charged with MgCl₂ (15.0 mmol). Both of these operations are performed in an argon atmosphere drybox. The flasks are then transferred to a manifold system and fitted with argon inlets. Freshly distilled THF (15 mL) is added to both flask A and B via a syringe. The mixtures are stirred at room temperature. The magnesium chloride/THF solution is transferred dropwise to flask A by a cannula at a rate that allows the color of the solution to remain green.

Spiroannelation

Initial attempts to prepare a (2-butene-1,4-diyl)magnesium complex by reacting 1,2-dimethylenecyclohexane with ordinary metallic magnesium were not successful. Highly reactive magnesium, prepared by the reduction of magnesium chloride with lithium using naphthalene as an electron carrier, reacted smoothly with 1,2-dimethylenecyclohexane in THF at ambient temperature, giving the corresponding (2-butene-1,4-diyl)magnesium complex in high yield.

In a typical preparation, 1,2-dimethylenecyclohexane (2.0 mmol) was added via a disposable syringe to the newly prepared highly reactive Mg (3.0-4.0 mmol) in THF (15 mL). The mixture was stirred for 3-4 hours at room temperature under argon. The yellowish gold THF solution of the complex was separated from the excess magnesium either by: filtration; or by transferring the solution via cannula to another flask after the mixture had settled and the solution had became transparent (approximately 2 hours). Bis-electrophiles were added to the freshly prepared THF solutions of the magnesium complexes of 1,2-dimethylenecycloalkanes at -78° C. The reaction mixture was then stirred at -78° C. for 1 hour prior to warm up. This same method can be extended to other 1,2-dimethylenecycloalkanes, such as 1,2-dimethylenecyclopentane and 1,2-dimethylenecycloheptane.

Significantly, treatment of this type of (2-butene-1,4-diyl)magnesium complex, i.e., those resulting from the reaction of highly reactive magnesium with cycloalkanes having two conjugated exocyclic double bonds, with bis-electrophiles, especially 1,n-dibromoalkanes, gave spirocycles in good to excellent yields. The results are summarized in Table I. A major advantage of using (2-butene-1,4-diyl)magnesium complexes is that spiroannelation can be achieved in one synthetic operation.

                                      TABLE I                                      __________________________________________________________________________     Reactions of the Magnesium Complexes of                                        1,2-Dimethylenecycloalkanes with Bis-electrophiles                             Diene.sup.a                                                                        Electrophile                                                                           Conditions                                                                           Product.sup.b  % Yield.sup.c                                 __________________________________________________________________________     1   Br(CH.sub.2).sub.5 Br                                                                  -78° C. to reflux                                                              ##STR1##      45                                            1   Br(CH.sub.2).sub.4 Br                                                                  -78° C. to reflux                                                              ##STR2##      75 (81)                                       1   Br(CH.sub.2).sub.3 Br                                                                  -78° C. to room temp.                                                          ##STR3##      75 (87)                                       1   Br(CH.sub.2).sub.3 Br                                                                  -78° C. to -30° C.                                                      ##STR4##      78.sup.d                                      1   Br(CH.sub.2).sub.2 Br                                                                  -78° C. to room temp.                                                          ##STR5##      -- (15).sup.e                                 1   TsO(CH.sub.2).sub.2 OTs                                                                -78° C. to room temp.                                                          ##STR6##      52 (67).sup.e                                 2   Br(CH.sub.2).sub.3 Br                                                                  -78° C. to room temp.                                                          ##STR7##      60 (70)                                       3   Br(CH.sub.2).sub.3 Br                                                                  -78° C. to room temp.                                                          ##STR8##      77 (86)                                       __________________________________________________________________________      .sup.a 1: 1,2Dimethylenecyclohexane; 2: 1,2Dimethylenecyclopentane; 3:         1,2Dimethylenecycloheptane.                                                    .sup.b All new compounds have been fully characterized by .sup.1 H NMR,        .sup.13 C NMR, IR and mass spectra.                                            .sup.c Isolated overall yields were based on 1,2dimethylenecycloalkanes.       GC yields are shown in parentheses.                                            .sup.d Protonation of the intermediate at -30° C. resulted in           monoalkylation, yielding the corresponding bromoolefin containing a            quarternary center.                                                            .sup.e Attempts to generate a fourmembered ring by treating the                (2butene-1,4-diyl)magnesium complex generated from 1a with 1,2                 dibromoethane gave only low yields of 5methylenespiro[3.5]nonane. This         spirocycle was prepared in good yield by the use ethylene glycol di            p-tosylate in place of 1,2dibromoethane in THF at -78° C. followed      by warming to room temperature.                                          

Keto-Functionalized Carbocycles

The (2-butene-1,4-diyl)magnesium complexes prepared from the reaction of highly reactive magnesium with cycloalkanes having two conjugated exocyclic double bonds also react with bromoalkylnitriles to generate keto-functionalized carbocycles. These magnesium complexes of 1,2-dimethylenecycloalkanes were prepared as described above. The bromonitriles were added to the THF solution of these complexes at -78° C. The reaction mixture was then stirred at -78° C. for 30 minutes prior to warming to room temperature. This was followed by adding H₃ O⁺ to the solutions. Table II summaries the results of these studies.

                  TABLE II                                                         ______________________________________                                         Reactions of the Magnesium Complexes of                                        1,2-Dimethylenecycloalkanes with Bromoalkylnitriles                                                                 %                                         Diene.sup.a                                                                          Bromonitrile                                                                              Product.sup.b       Yield.sup.c                               ______________________________________                                         1     BrCH.sub.2 CN                                                                              ##STR9##           46                                        1     Br(CH.sub.2).sub.2 CN                                                                      ##STR10##          51                                        1     Br(CH.sub.2).sub.3 CN                                                                      ##STR11##          13                                        1     Br(CH.sub.2).sub.3 CN                                                                      ##STR12##          .sup. 61.sup.d                            2     Br(CH.sub.2).sub.2 CN                                                                      ##STR13##          40                                        3     Br(CH.sub.2).sub.2 CN                                                                      ##STR14##          54                                        ______________________________________                                          .sup.a 1: 1,2Dimethylenecyclohexane; 2: 1,2Dimethylenecyclopentane; 3:         1,2Dimethylenecycloheptane.                                                    .sup.b All compounds have been completely characterized spectroscopically      .sup.c Isolated overall yields were based on 1,2dimethylenecycloalkanes.       .sup.d Protonation at -40° C. resulted in the survival of the cyan      group, establishing where the initial attack occurred.                   

Fused Ring Carbocyclic Alcohols and β,γ-Unsaturated Ketones

Table III lists representative results for the reactions of magnesium complexes of 1,2-dimethylenecycloalkanes with carboxylic esters and acid halides. This approach is of general synthetic utility for the preparation of fused carbocyclic alcohols or β,γ-unsaturated ketones depending on the reaction temperatures. For example, treatment of the magnesium complex of 1,2-dimethylenecyclohexane with ethyl acetate at low temperatures (-78° C. to -10° C.) and quenching the reaction at -10° C. resulted in the formation of 2-methyl-1-cyclohexenyl-2-propanone in 72% isolated yield. On the other hand, warming the mixture to reflux followed by workup afforded a fused carbocyclic alcohol, in excellent yield.

The magnesium complexes of 1,2-dimethylenecycloalkanes were prepared as described above. The temperature of the reaction of each of these complexes with carboxylic esters or acid halides was typically maintained at or below -10° C. in order to obtain an enone product. In contrast, the reaction mixture was typically refluxed for complete formation of a fused carbocycle product. Satisfactory results were obtained in the reactions using ethyl acetate, ethyl butyrate, ethyl benzoate, and acetyl chloride.

                                      TABLE III                                    __________________________________________________________________________     Reactions of the Magnesium Complexes of                                        1,2-Dimethylenecycloalkanes with Esters and Acetyl Chloride                    Diene.sup.a                                                                        RC(O)X   Conditions.sup.b                                                                     Product.sup.c      % Yield.sup.d                            __________________________________________________________________________     1   CH.sub.3 COOEt                                                                          A                                                                                     ##STR15##         91                                       1   CH.sub.3 COOEt                                                                          B                                                                                     ##STR16##         72                                       1   CH.sub.3 COOEt then CH.sub.3 COCl                                                       C                                                                                     ##STR17##         75                                       1   CH.sub.3 CH.sub.2 COOEt                                                                 A                                                                                     ##STR18##         96                                       1   CH.sub.3 CH.sub.2 COOEt                                                                 B                                                                                     ##STR19##         81                                       1   PhCOOEt  A                                                                                     ##STR20##         55                                       1   PhCOOEt  B                                                                                     ##STR21##         62                                       2   CH.sub.3 CH.sub.2 COOEt                                                                 A                                                                                     ##STR22##         59                                       2   CH.sub.3 CH.sub.2 COOEt                                                                 B                                                                                     ##STR23##         76                                       3   CH.sub.3 CH.sub.2 COOEt                                                                 A                                                                                     ##STR24##         74                                       3   CH.sub.3 CH.sub.2 COOEt                                                                 B                                                                                     ##STR25##         84                                       1   CH.sub.3 COCl                                                                           A                                                                                     ##STR26##         69                                       1   CH.sub.3 COCl                                                                           D                                                                                     ##STR27##         58                                       1   2CH.sub.3 COCl                                                                          E                                                                                     ##STR28##         88                                       __________________________________________________________________________      .sup.a 1: 1,2Dimethylenecyclohexane; 2: 1,2Dimethylenecyclopentane;            3:1,2Dimethylenecycloheptane.                                                  .sup.b Conditions "A": stir at -78° C. for 30 minutes, allow            solution to warm to room temperature, and then reflux for 30 minutes.          Conditions "B": stir at -78° C. for 30 minutes, allow solution to       warm to -10° C., and then stir at -10° C. for 1 hour.            Conditions "C": stir at -78° C. for 30 minutes, allow solution to       warm to -10° C., and then stir at -10° C. for 1 hour, add        CH.sub.3 COCl at -20° C. and stir for 30 minutes, warm to room          temperature.                                                                   Conditions "D": stir at -78° C. for 30 minutes, allow solution to       warm to -20° C., and then stir at -20° C. for 30 minutes.        Conditions "E": stir at -78° C. for 30 minutes, allow solution to       warm to room temperature.                                                      .sup.c All new compounds have been fully characterized by .sup.1 H NMR,        .sup.13 C NMR, IR and mass spectra.                                            .sup.d Isolated overall yields were based on 1,2dimethylenecycloalkanes. 

γ-Lactones Including Spiro γ-Lactones

The (2-butene-1,4-diyl)magnesium complexes prepared from the reaction of highly reactive magnesium with either cyclic hydrocarbons having at least two conjugated exocyclic double bonds or open-chain conjugated dienes also react with a ketone or aldehyde and carbon dioxide to form γ-lactones, preferably spiro γ-lactones. Magnesium complexes of 1,2-dimethylenecycloalkanes and 1,3-butadienes were prepared as described above. A molar equivalent of a ketone was added to the THF solution of these complexes at -78° C. The reaction mixture was then stirred for ten minutes, warmed to a temperature of 0° C. to 25° C., and bubbled with carbon dioxide for twenty minutes prior to acidic hydrolysis and warming to about 40° C. Table IV summarizes the results of these studies.

In a typical reaction 1,2-dimethylenecyclohexane (0.239 g, 2.21 mmol) was added via a disposable syringe to the highly reactive magnesium (3.53 mmol) in THF (20 mL). After being stirred at room temperature for 4 hours, the reaction mixture was allowed to stand until the solution became transparent (approximately 2 hours). The yellowish gold THF solution of the complex was then separated from the excess magnesium by cannulating the solution to another flask under argon. The THF solution of newly formed magnesium complex of 1,2-dimethylenecyclohexane was cooled to -78° C. using a dry ice/acetone bath, and acetone (0.122 g, 2.10 mmol) was added via a disposable syringe. The mixture was stirred at -78° C. for 10 minutes, then gradually warmed to 0° C. Carbon dioxide was then bubbled through the reaction mixture for 10 minutes at 0° C., and another 10 minutes at room temperature. An aqueous solution of 1.5N HCl (10 mL) was added at 0° C. The reaction mixture was slightly heated at 40° C. for 1 hour. After cooling to room temperature, the mixture was extracted with diethyl ether (3×20 mL). The combined organic phases were washed with saturated aqueous NaHCO₃ (2×20 mL) and brine (20 mL) and dried over anhydrous MgSO₄. Removal of solvents and flash column chromatography gave 4,4-dimethyl-6-methylene-3-oxaspiro[4.5]decan-2-one (0.279 g) in 68% yield. The following scheme illustrates this route for spiro γ-lactone synthesis. ##STR29##

Referring to the above scheme, initially it was observed that treatment of 1,2-dimethylenecyclohexane-magnesium (2) with one molar equivalent of acetone at -78° C. resulted in the formation of a 1,2-addition adduct (3) derived from the incorporation of one molecule of acetone with the diene complex. (The actual structure of this complex is unknown.) Protonation of the adduct (3) at -78° C. yielded a tertiary alcohol containing a quaternary center (4). Carbon dioxide was bubbled as a second electrophile through the reaction mixture at 0° C. to room temperature. Intermediate (3) reacted quickly with carbon dioxide, yielding presumably a magnesium salt of an organic molecule containing both an alkoxy and a carboxylate group (5). After acidic hydrolysis followed by slight warming, a spiro γ-lactone, 4,4-dimethyl-6-methylene-3-oxaspir[4.5]decan-2-one (7) was obtained. Treatment of (2) with two molar equivalents of acetone at -78° C. followed by acidic hydrolysis at -78° C. also yielded (4), indicating that the initially formed adduct (3) did not undergo further addition with unreacted acetone under the reaction conditions. Thus, both acetone and subsequently added CO₂ were delivered to the original diene at desired positions.

Significantly, this approach can also be used to prepare spiro γ-lactones containing two spiro centers. The representative examples of this dispiroannulation are listed in Table IV (Entries 2 and 3). For example, (2) was treated with cyclopentanone at -78° C. and the reaction mixture was then bubbled with CO₂ at 0° C. to room temperature. Workup gave 11-methylene-14-oxadispiro[4.0.5.3]tetradecan-13-one in 66% isolated yield (Table IV, Entry 2). Similar chemistry was observed when cyclohexanone was used as the first electrophile (Table IV, Entry 3).

A notable advantage of this new γ-lactone synthesis is that the construction of a quaternary center and the introduction of both a hydroxyl and a carboxyl used for lactonization are accomplished in one synthetic operation. Remarkably, this chemistry has been easily extended to the magnesium complex of acyclic 1,3-diene. The following scheme gives an outline for the synthesis of spiro γ-lactones from (2,3-dimethyl-2-butene-1,4-diyl)magnesium (11). Generally, reaction of a cyclic ketone with (11) at -78° C. resulted in initial attach at the 2-position of the diene complex, giving an internal alkoxy Grignard (12). After warming up, the intermediate was allowed to react with carbon dioxide at 0° C. to room temperature. Upon hydrolysis and gentle heating, a spiro γ-lactone containing a quaternary center was obtained (14) (Table IV, Entries 4 and 5). The method is equally useful for the preparation of γ-lactones. Use of an acyclic ketone or aldehyde instead of a cyclic ketone will result in the synthesis of the corresponding γ-lactone. ##STR30##

                  TABLE IV                                                         ______________________________________                                         Synthesis of Spiro γ-Lactones from                                       Conjugated Diene, Ketone and CO.sub.2                                          Entry  Diene.sup.a                                                                            Ketone.sup.b                                                                             Product.sup.c                                                                               % Yield.sup.d                            ______________________________________                                         1      1       Acetone                                                                                               68                                       2      1       Cyclo- pentanone                                                                          ##STR31##   66                                       3      1       Cyclo- hexanone                                                                           ##STR32##   60                                       4      4       Cyclo- pentanone                                                                          ##STR33##   68                                       5      4       Cyclo- hexanone                                                                           ##STR34##   61                                       ______________________________________                                          .sup.a 1: 1,2Dimethylenecyclohexane; 4: 2,3Dimethyl-1,3-butadiene.             .sup.b Ketone was added to the dienemagnesium complex at -78° C.        and the mixture was stirred at -78° C. for 10 minutes, then             gradually warmed to 0° C. followed by the bubbling of CO.sub.2.         .sup.c All products have been fully characterized spectroscopically,           including .sup.1 H NMR, .sup.13 C NMR, FTIR, MS and high resolution mass       spectra.                                                                       .sup.d Isolated yields.                                                  

Spiroheterocycles

Spiroheterocyclic compounds, particularly silicon-containing spiroheterocyclic compounds, can be prepared from the reaction of unsymmetrical (2-butene-1,4-diyl)magnesium complexes with a tetrahalide reagent of the formula MX₄ (wherein M=Si, Ge, Sn, Pb and X=F, Cl, Br, I). Preferably, a silicon tetrahalide is used for the preparation of silicon-containing spiroheterocycles. The results for silicon-containing spiroheterocycles are summarized in Table V.

In a typical reaction, (2-methyl-2-butene-1,4-diyl)magnesium in 20 mL of THF, which was freshly prepared from isoprene (0.250 g, 3.67 mmol) and excess highly reactive magnesium, was cooled to -78° C. SiCl₄ (0.256 g, 1.50 mmol) was added via a disposable syringe. There was an instantaneous disappearance of a pale orange color. After being stirred at -78° C. for 1 hour, the mixture was gradually warmed to 0° C. and an aqueous solution of 1.5N HCl (15 mL) was added. The reaction mixture was washed with diethyl ether (20 mL). The aqueous layer was extracted with diethyl ether (2×20 mL). The organic portions were combined, washed with saturated aqueous NaHCO₃ (2×20 mL) and brine (15 mL), and dried over anhydrous Na₂ SO₄. Evaporation of solvents and flash column chromatography afforded 2,7-dimethyl-5-silaspiro[4,4]nona-2,7-diene. This compound has been previously reported to be difficult to prepare; however, utilization of magnesium complexes of 1,3-dienes allows the preparation to be carried out under extremely mild conditions.

                                      TABLE V                                      __________________________________________________________________________     Preparation of Silicon-Containing Spiroheterocycles                            from Substituted (2-butene-1,4-diyl)Magnesium                                  Diene.sup.a                                                                        Electrophile.sup.b                                                                    Product(s).sup.c        % Yield                                     __________________________________________________________________________     4   SiCl.sub.4                                                                             ##STR35##              75                                          5   SiCl.sub.4                                                                             ##STR36##              62                                          6   SiCl.sub.4                                                                             ##STR37##              34                                          __________________________________________________________________________      .sup.a 4: isoprene; 5: myrcene; 6: 2phenyl-1,3-butadiene.                      .sup.b Electrophiles were added to the THF solution of substituted             (2butene-1,4-diyl)magnesium complexes at -78° C. The reaction           mixture was stirred at -78° C. for 30 minutes then warmed to            0° C. prior to workup.                                                  .sup.c All new compounds were completely characterized spectroscopically.

2,7-Dimethyl-5-silaspiro[4,4]nona-2,7-diene

(0.185 g, 75% yield): ¹ H NMR δ 5.53 (m, 2 H), 1.77 (t, J=1.0 Hz, 6 H), 1.48 (d, J=1.1 Hz, 4 H), 1.40 (s, 4 H); ¹³ C NMR δ 140.2, 124.9, 22.6, 21.8, 17.8; IR (neat) 3005, 2958, 2927, 2908, 2879, 2848, 1637, 1448, 1433, 1213, 1161, 1022, 756 cm⁻¹ ; EIMS m/z (relative intensity) 164 (M.sup..+, 73), 149 (3), 136 (8), 122 (12), 109 (4), 96 (100).

2,7-Di(4-methyl-3-pentenyl)-5-silaspiro[4,4]nona-2,7-diene

(62% yield): ¹ H NMR δ 5.55 (s, 2 H), 5.09 (s, 2 H), 2.09 (s, 8 H), 1.67 (s, 6 H), 1.59 (s, 6 H), 1.47 (s, 4 H), 1.40 (s, 4 H); ¹³ C NMR δ 144.2, 131.3, 124.5, 124.1, 36.8, 26.4, 25.7, 19.4, 17.7, 17.3; IR (neat) 3001, 2966, 2912, 2879, 1631, 1448, 1375, 1161, 823, 760; EIMS m/z (relative intensity) 300 (M.sup..+, 15), 257 (6), 231 (9), 203 (4), 175 (5), 163 (100), 135 (6), 121 (3), 109 (7), 95 (13), 69 (44); HRMS calcd for C₂₀ H₃₂ Si: 300.2273, found: 300.2278. Anal. calcd: C, 79.93; H, 10.73. Found: C, 80.24; H, 11.12.

2,7 -Diphenyl-5-silaspiro[4,4]nona-2,7-diene

(34% yield): ¹ H NMR δ 7.55-7.49 (m, 4), 7.36-7.20 (m, 6 H), 6.44 (s, 2 H), 1.96 (s, 4 H), 1.80 (s, 4 H); ¹³ C NMR δ 141.9, 140.4, 128.2, 127.1, 126.8, 125.6, 18.3, 18.2; IR (neat) 3080, 3057, 3020, 2916, 2879, 1604, 1493, 1444, 1159, 997, 767, 742, 694 cm⁻¹ ; EIMS m/z (relative intensity) 288 (M.sup..+, 100), 158 (57), 105 (15), 71 (14); HRMS calcd for C₂₀ H₂₀ Si: 288.1334, found: 288.1328.

Regioselective Reactions

Unsymmetrical (2-butene-1,4-diyl)magnesium complexes were prepared as follows. Isoprene, myrcene, or 2-phenyl-1,3-butadiene was added to an excess of newly generated highly reactive magnesium in 20 mL of THF (typical ratio of Mg:diene=1.5:1 to 1.8:1). After being stirred at room temperature for 2 hours, the reaction mixture was allowed to stand until the solution became transparent (approximately 3 hours). Then the upper clear solution of magnesium complex was transferred via a cannula to another flask under argon. The appropriate electrophile was then added to this magnesium complex.

In a typical regioselective reaction of an unsymmetrical (2-butene-1,4-diyl)magnesium complex, a THF solution of the complex (20 mL) prepared from isoprene (0.281 g, 2.06 mmol, technical grade) and activated magnesium (3.44 mmol) was cooled to -78° C. Me₃ SiCl (0.171 g, 1.57 mmol) was added via a disposable syringe. The reaction mixture was stirred at -78° C. for 1 hour, and then it was gradually warmed to 0° C. Excess cyclohexanone (0.278 g, 2.83 mmol) was added at 0° C. The reaction mixture was warmed to room temperature and stirred for 1 hour. An aqueous solution of HCl (1.5N, 10 mL) was added at 0° C. The mixture was washed with diethyl ether (20 mL), and the aqueous layer was extracted with diethyl ether (2×20 mL). The combined organic phases were washed with a saturated aqueous solution of NaHCO₃ (2×15 mL) and brine (20 mL) and dried over MgSO₄. Removal of solvents and flash column chromatography (eluted by hexanes/Et₂ O, 98:2) gave 1-(2-methyl-1-trimethylsilylmethyl-2-propenyl)cyclohexanol as the major isomer (0.372 g, 77%) and 1-(1-methyl-1-trimethylsilylmethyl-2-propenyl)cyclohexanol as the minor isomer (0.025 g, 5%) the major isomer was eluted out before the minor isomer in 82% total yield.

                                      TABLE VI                                     __________________________________________________________________________     Regioselective Reactions of Unsymmetrical (2-butene-1,4-diyl)magnesium         Complexes with Two Different Electrophiles                                     Diene.sup.a                                                                        R.sub.3 SiCl.sup.b                                                                     Product(s).sup.c,d                % Yield                          __________________________________________________________________________     4   (CH.sub.3).sub.3 SiCl                                                                   ##STR38##                        91                               4   ( n-Butyl).sub.3 SiCl                                                                   ##STR39##                        94                               5   (CH.sub.3).sub.3 SiCl                                                                   ##STR40##                        82                               5   ( n-Butyl).sub.3 SiCl                                                                   ##STR41##                        94                               6   (CH.sub.3).sub.3 SiCl                                                                   ##STR42##                        95                               6   ( n-Butyl).sub.3 SiCl                                                                   ##STR43##                        92                               __________________________________________________________________________      .sup.a 4: isoprene; 5: myrcene; 6: 2phenyl-1,3-butadiene.                      .sup.b R.sub.3 SiCl was added at -78° C. The reaction mixture was       stirred at -78° C. for 1 hour and then warmed to 0° C. prio      to the addition of cyclohexanone.                                              .sup.c The compositions of all products (or major isomers) were determine      by high resolution mass spectroscopy and/or elemental analyses. The            structures of all compounds were established by .sup.1 H NMR, .sup.13 C        NMR, IR and mass spectra.                                                      .sup.d Ratios of isomers were given in parenthesis. Individual isomers         were separated by chromatography.                                        

1-(2-Methyl-1-trimethylsilylmethyl-2-propenyl)cyclohexanol or 1-(1-Methyl-1-trimethylsilylmethyl-2-propenyl)cyclohexanol

(77:23, 91% total yield). Major isomer: ¹ H NMR δ 4.85 (m, 1 H), 4.76 (m, 1 H), 2.14 (dd, J=11.7, 3.4 Hz, 1 H), 1.74 (dd, J=1.2, 0.7 Hz, 3 H), 1.65-1.10 (m, 10 H), 0.82-0.68 (m, 2 H), -0.03 (s, 9 H); ¹³ C NMR 147.0, 114.1, 73.0, 52.6, 35.6, 35.5, 25.8, 22.3, 22.1, 14.0, -1.1; IR (neat) 3487 (br), 3068, 2933, 2858, 1639, 1448, 1373, 1246, 964, 889, 862, 841 cm⁻¹ ; HRMS (FAB) calcd for [C₁₄ H₂₈ OSi+Li]+: 247.2070, found: 247.2075. Anal. Calcd for C₁₄ H₂₈ OSi: C, 69.93; H, 11.74. Found: C, 69.46; H, 11.97. Minor isomer: ¹ H NMR δ 5.91 (dd, J=17.6, 10.8 Hz, 1 H), 5.13 (dd, J=10.8, 1.6 Hz, 1 H), 5.01 (dd, J=17.6, 1.6 Hz, 1 H), 1.67-1.20 (m, 10 H), 1.08 (d, J=1.0 Hz, 3 H) , 0.95 (dd, J=14.2, 1.0 Hz, 1 H), 0.80 (d, J=14.2 Hz, 1 H), -0.01 (s, 9 H); ¹³ C NMR δ 145.6, 114.0, 75.3, 46.8, 31.3, 30.5, 25.8, 24.2, 22.2, 22.0, 19.4, 1.00; IR (neat) 3492 (br), 3080, 2935, 2860, 1631, 1448, 1415, 1375, 1248, 1223, 910, 864, 839 cm⁻¹ ; EIMS m/z (relative intensity) 225 ([M--CH₃ ]⁺, 0.7) , 207 (0.6), 183 (0.3), 171 (5.3), 142 (12), 99 (27), 73 (100); HRMS calcd for C₁₄ H₂₈ OSi and [M--CH₃ ]: 240.1909, 225.1675, found: 240.1897 (EI Peak Match ), 225.1678.

1-(2-Methyl-1-tri(n-butyl)silylmethyl-2-propenyl)cyclohexanol and 1-(1-Methyl-1-(tri-n-butyl)silylmethyl-2-propenyl)cyclohexanol

(92:8, 94% total yield). Major isomer: ¹ H NMR δ 4.85 (m, 1 H), 4.77 (d, J=1.9 Hz, 1 H), 2.12 (dd, J=8.5, 6.1 Hz, 1 H), 1.76 (d, J=0.4 Hz, 3 H), 1.68-1.10 (m, 22 H), 0.87 (t, J=7.0 Hz, 9 H), 0.76-0.70 (m, 2 H), 0.52-4.44 (m, 6 H) ; ¹³ C NMR δ 147.2, 114.1, 73.2, 52.3, 35.6, 35.5, 26.9, 26.2, 25.9, 22.3, 22.2, 13.8, 12.4, 9.8; IR (neat) 3491 (br), 3068, 2954, 2924, 2870, 2856, 1637, 1456, 1375, 1196, 1082, 964, 887 cm⁻¹ ; EIMS m/z (relative intensity) 309 ([M--C₄ H₉ ]⁺, 0.5), 297 (4.3), 268 (7.8), 199 (100), 143 (67), 99 (19); HRMS calcd for C₂₃ H₄₆ OSi and C₂₂ ¹³ CH₄₆ OSi: 366.3318, 367.3347, found (EI Peak Match): 366.3301, 367.3338. Anal. Calcd: C, 75.33; H, 12.64. Found: C, 75.60; H, 12.77. Minor Isomer (difficult to isolate): ¹ H NMR δ 5.92 (dd, J=17.6, 10.8 Hz, 1 H), 5.11 (dd, J=10.8, 1.2 Hz, 1 H), 5.01 (dd, J=17.6, 1.2 Hz, 1 H), 1.70-1.10 (m, 22 H), 1.07 (s, 3 H), 0.88 (t, J=7.0 Hz, 9 H), 0.95-0.75 (m, 2 H), 0.53-0.45 (m, 6 H).

1-(2-(4-Methyl-3-pentenyl)-1-trimethylsilylmethyl-2-propenyl)cyclohexanol and 1-(1-Ethenyl-5-methyl-1-trimethylsilylmethyl-4-hexenyl) cyclohexanol

(94:6) Major isomer: ¹ H NMR δ 5.17-5.09 (m, 1 H, 4.89 (s, 1 H), 4.86 (s, 1 H), 2.20-2.00 m, 5 H), 1.67 (s, 3 H), 1.60 (s, 3 H), 1.68-1.05 (m, 10 H), 0.84-0.69 (m, 2 H), 0.03 (s, 9 H); ¹³ C NMR δ 151.1, 131.5, 124.4, 111.4, 73.2, 53.0, 35.6, 35.5, 25.9, 25.8, 25.7, 22.3, 22.1, 17.6, 14.9, -0.9; IR (neat) 3485 (br), 3080, 2931, 2858, 1633, 1448, 1375, 1246, 972, 891, 860, 837 cm⁻¹ ; EIMS m/z (relative intensity) 290 ([M--H₂ O].+, 0.3), 275 (0.2), 210 (7), 171 (28), 141 (87), 99 (16), 73 (100); HRMS calcd for C₁₉ H₃₆ OSi and C₁₈ ¹³ CH₃₆ OSi: 308.2535, 309.2563, found (HREI Peak Match): 308.2530, 309.2559. Anal. Calcd: C, 73.96; H, 11.76. Found: C, 74.15; H, 11.80. Minor isomer: ¹ H NMR δ 5.81 (dd, J=17.6, 11.0 Hz, 1 H), 5.15-4.95 (m, 3 H), 2.10-0.95 (m, 14 H), 1.65 (s, 3 H), 1.59 (s, 3 H), 0.91 (d, J=15.0 Hz, 1 H), 0.75 (d, J=15.0 Hz, 1 H), 0.04 (s, 9 H); ¹³ C NMR δ 145.5, 131.0, 125.3, 114.1, 75.8, 50.6, 33.3, 31.6, 31.5, 25.7, 24.0, 22.0, 21.8, 19.8, 17,8, 1.6; IR (neat) 3566 (br), 3080, 2933, 2858, 1631, 1450, 1375, 1259, 1246, 1155, 958, 912, 860, 845 cm⁻¹.

1-(2-(4-Methyl-3-pentenyl)-1-tri(n-butyl)silylmethyl-2-propenyl)cyclohexano

(94% yield): ¹ H NMR δ 5.17-5.09 (m, 1 H), 4.89 (s, 1 H), 4.88 (s, 1 H), 2.20-2.03 (m, 5 H), 1.67 (s, 3 H), 1.60 (s, 3 H), 1.70-1.10 (m, 22 H), 0.86 (t, J=7.2 Hz, 9 H), 0.78-0.73 (m, 2 H), 0.50-0.43 (m, 6 H); ¹³ C NMR δ 151.2, 131.5, 124.3, 111.0, 73.4, 52.6, 35.6, 35.3, 26.9, 26.1, 25.9, 25.8, 25.7, 22.3, 22.1, 17.6, 13.8, 12.5, 10.5; IR (neat) 3491 (br), 3080, 2954, 2922, 2870, 2856, 1633, 1456, 1375, 1194, 964, 887 cm⁻¹ ; EIMS m/z (relative intensity) 336 ([M--C₆ H₁₀ O].sup..+, 2.3), 297 (1.9), 199 (100), 159 (39), 143 (53), 103 (18); HRMS calcd for C₂₈ H₅₄ OSi and C₂₇ ¹³ CH₅₄ OSi: 434.3944, 435.3973, found (EI Peak Match): 434.3932, 435.3961. Anal. Calcd: C, 77.34; H, 12.53. Found: C, 77.22; H, 12.42.

1-(2-Phenyl-1-trimethylsilylmethyl-2-propenyl)cyclohexanol

(95% yield): ¹ H NMR δ 7.43 (m, 2 H), 7.30 (m, 2 H), 7.23 (m, 1 H), 5.50 (s, 1 H), 5.16 (s, 1 H), 2.83 (t, J=6.9 Hz, 1 H), 1.69-1.00 (m, 10 H), 0.97 (d, J=6.9 Hz, 2 H), -0.03 (s, 9 H); ¹³ C NMR δ 150.5, 144.5, 128.3, 127.1, 126.6, 115.5, 74.1, 48.7, 35.6, 35.0, 25.7, 22.0, 21.9, 16.9, -0.5; IR (neat) 3483 (br), 3082, 3057, 3030, 2935, 2860, 1618, 1599, 1574, 1495, 1448, 1248, 966, 903, 862, 843, 704 cm⁻¹ ; EIMS m/z (relative intensity) 284 ([M--H₂ O].sup..+, 0.3), 272 (0.3), 204 (30), 130 (8), 99 (13), 73 (100); HRMS (FAB) calcd for [C₁₉ H₃₀ OSi+Li]: 309.2226, found: 309.2221.

1-(2-Phenyl-1-tri(n-butyl)silylmethyl-2-propenyl)cyclohexanol

(92% yield): ¹ H NMR δ 7.50-7.45 (m, 2 H), 7.35-7.28 (m, 2 H), 7.27-7.21 (m, 1 H), 5.53 (s, 1 H), 5.20 (s, 1 H), 2.83 (dd, J=11.3, 3.5 Hz, 1 H), 1.75-0.89 (m, 24 H), 0.85 (t, J=7.0 Hz, 9 H), 0.51-0.43 (m, 6 H); ¹³ C NMR δ 150.4, 144.2, 128.3, 127.1, 126.6, 115.0, 74.4, 48.6, 35.6, 34.9, 26.8, 26.1, 25.8, 22.0, 13.7, 12.7; IR (neat) 3487 (br), 3082, 3055, 3028, 2952, 2922, 2870, 2856, 1616, 1599, 1574, 1495, 1464, 1375, 1080, 964, 903, 706 cm⁻¹ ; EIMS m/z (relative intensity) 330 ([M--C₆ H₁₀ O].sup..+, 2.2), 273 (1.2), 199 (38), 143 (68), 101 (18), 69 (100); HRMS calcd for C₂₈ H₄₈ OSi and C₂₇ ¹³ CH₄₈ OSi: 428.3474, 429.3504, found (EI Peak Match): 428.3467, 429.3507.

The foregoing detailed description has been given for clarity of understanding only and no unnecessary limitations are to be understood therefrom. The invention is not limited to the exact details shown and described, for obvious modifications will occur to those skilled the art. 

What is claimed is:
 1. A method for the preparation of a spiroheterocycle comprising:(a) contacting a magnesium (II) salt in an ethereal, polyethereal, or hydrocarbon solvent with a reducing agent having a reduction potential of about -1.5 volts, or more negative, relative to SCE, to form a highly reactive magnesium species; (b) contacting the highly reactive magnesium species with an unsymmetrical 1,3-diene to form an unsymmetrical (2-butene-1,4-diyl) magnesium complex; and (c) contacting the unsymmetrical (2-butene-1,4-diyl) magnesium complex with a tetrahalide reagent of the formula MX₄, wherein M=Ge, Sn, Pb and X=F, Cl, Br, I, to form a spiroheterocycle.
 2. The method of claim 1 wherein the highly reactive magnesium species is contacted with an unsymmetrical 1,3-diene selected from the group consisting of isoprene, myrcene, and 2-phenyl-1,3-butadiene, to form an unsymmetrical (2-butene-1,4-diyl)magnesium complex.
 3. The method of claim 2 wherein the tetrahalide reagent is SiCl₄.
 4. A method for the control of the regioselectivity of electrophilic attack of unsymmetrical (2-butene-1,4-diyl)magnesium complexes comprising reacting the unsymmetrical (2-butene-1,4-diyl)magnesium complex with a triorganosilyl chloride prior to adding a second electrophile.
 5. A method for preparation of a fused ring carbocyclic alcohol comprising:(a) contacting a magnesium(II) salt in an ethereal, polyethereal, or hydrocarbon solvent with a reducing agent having a reduction potential of about -1.5 volts, or more negative, relative to SCE, to form a highly reactive magnesium species; (b) contacting the highly reactive magnesium species with a cyclic hydrocarbon containing at least two conjugated exocyclic double bonds to form a (2-butene-1,4-diyl)magnesium complex; and (c) contacting the (2-butene-1,4-diyl)magnesium complex with a carboxylic ester or acid halide in an ethereal or polyethereal solvent at a temperature of about 25° C. or greater to form a fused ring carbocyclic alcohol.
 6. The method of claim 5 wherein the step of contacting the (2-butene-1,4-diyl)magnesium complex with a carboxylic ester or acid halide in an ethereal or polyethereal solvent comprises contacting the (2-butene-1,4-diyl)magnesium complex with a carboxylic ester or acid halide in an ethereal or polyethereal solvent to form a spirocyclic fused ring carbocyclic alcohol.
 7. The method of claim 5 wherein the reducing agent used in the preparation of the highly reactive magnesium species is an alkali metal.
 8. The method of claim 5 wherein the cyclic hydrocarbon is a cycloalkane containing at least two conjugated exocyclic double bonds.
 9. A method for preparation of a carbocycle containing a β,γ-unsaturated ketone functionality comprising:(a) contacting a magnesium(II) salt in an ethereal, polyethereal, or hydrocarbon solvent with a reducing agent having a reduction potential of about -1.5 volts, or more negative, relative to SCE, to form a highly reactive magnesium species; (b) contacting the highly reactive magnesium species with a cyclic hydrocarbon containing at least two conjugated exocyclic double bonds to form a (2-butene-1,4-diyl)magnesium complex; and (c) contacting the (2-butene-1,4-diyl)magnesium complex with a carboxylic ester or acid halide in an ethereal or polyethereal solvent at a temperature of below -10° C. to form a carbocycle containing a β,γ-unsaturated ketone functionality.
 10. The method of claim 9 wherein the step of contacting the (2-butene-1,4-diyl)magnesium complex with a carboxylic ester or acid halide in an ethereal or polyethereal solvent comprises contacting the (2-butene-1,4-diyl)magnesium complex with a carboxylic ester or acid halide in an ethereal or polyethereal solvent to form a spirocyclic carbocycle containing a β,γ-unsaturated ketone functionality.
 11. The method of claim 9 wherein the reducing agent used in the preparation of the highly reactive magnesium species is an alkali metal.
 12. The method of claim 9 wherein the cyclic hydrocarbon is a cycloalkane containing at least two conjugated exocyclic double bonds.
 13. A method for preparation of a carbocyclic spirocycle containing a three-membered ring comprising:(a) contacting a magnesium(II) salt in an ethereal, polyethereal, or hydrocarbon solvent with a reducing agent having a reduction potential of about -1.5 volts, or more negative, relative to SCE, to form a highly reactive magnesium species; (b) contacting the highly reactive magnesium species with a cyclic hydrocarbon containing at least two conjugated exocyclic double bonds to form a (2-butene-1,4-diyl)magnesium complex; and (c) contacting the (2-butene-1,4-diyl)magnesium complex with a carboxylic ester or first acid halide in an ethereal or polyethereal solvent at a temperature of below -10° C.; and (d) adding a second acid halide to form a carbocyclic spirocycle containing a three-membered ring.
 14. The method of claim 13 wherein the cyclic hydrocarbon is a cycloalkane containing at least two conjugated exocyclic double bonds.
 15. A method for preparation of a keto-functionalized spirocarbocycle comprising:(a) contacting a magnesium(II) salt in an ethereal, polyethereal, or hydrocarbon solvent with a reducing agent having a reduction potential of about -1.5 volts or more negative relative to SCE, to form a highly reactive magnesium species; (b) contacting the highly reactive magnesium species with a cyclic hydrocarbon having two conjugated exocyclic double bonds to form a (2-butene-1,4-diyl magnesium complex; and (c) contacting the (2-butene-1,4-diyl) magnesium complex with a bromoalkylnitrile in an ethereal or polyethereal solvent to form a keto-functionalized spirocarbocycle.
 16. The method of claim 15 wherein the reducing agent used in the preparation of the highly reactive magnesium species is an alkali metal.
 17. The method of claim 15 wherein the cyclic hydrocarbon is a cycloalkane containing at least two conjugated exocyclic double bonds.
 18. The method of claim 15 wherein the (2-butene-1,4-diyl)magnesium complex is contacted with the bromoalkylnitrile at a temperature of about -78° C. 